Emeritus Professor at University of Turin, he has been Full Professor of Nephrology at University of Turin, Adjoint Professor of Medicine at Brown University, Full Professor of Nephrology and Clinical Immunology at University of Pavia, and Full Professor at the II University of Naples.
At University of Turin, he has been Director of the PhD program in Medical Pathophysiology, Member of the Council of the School of Medicine, Director of the Stem Cell Laboratory at Molecular Biotechnology Centre, Renal Immunopathology Laboratory at Department of Medical Sciences, Vascular and Renal, Physiopathology at Centro di Medicina Sperimentale (CeRMS), President of Scientific Committee of Translational Center for Regenerative Medicine, President of the Course of Medical Biotechnology, Director of Department of Internal Medicine and of the PhD school in complex systems in medicine and Life sciences.
The scientific activity was focused on: 1. the biochemical characterization, cellular origin and biological activities of platelet-activating factor, 2. experimental models of kidney and lung injury, 3. marrow and tissue derived stem cell separation and characterization, 4. renal immunopathology, 5. inflammatory and tumour angiogenesis, 6. purification and characterization of stem cell derived extracellular vesicles and characterization of their mRNA and miRNA content. In particular, he investigated the role of extracellular vesicles in the paracrine action of progenitors/stem cells and their possible therapeutic applications.
He has been the principal investigator of several research programs funded by Ministero dell’Istruzione, Università e Ricerca (MIUR), Consiglio Nazionale delle Ricerche (CNR), Associazione Italiana per la Ricerca sul Cancro (AIRC), Consorzio Nazionale per la Ricerca sulle Cellule Staminali (CONSTEM), European Foundation for the Study of Diabetes, CEE, Kistem Project, European 6th Framework Programme on Research, Technological Development and Demonstration, and Marie Curie Actions; Nanotechnology.
He served as referee for the following research agencies: Wellcome Trust (UK); Cancer Research UK; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; German Federal Ministry of Education and Research, Ministero Istruzione Università e Ricerca, Istituto Superiore di Sanità, Israel Science Foundation, Swiss National Science Foundation, National Institutes of Health (NIH), USA.
He served in the Editorial Board of several journals, including PLosOne, American Journal of Cancer Research, Journal of Nephrology, International Journal of Molecular Medicine, and as referee for several journals, including Blood, Nature Medicine, Journal Experimental Medicine, The Journal of American Society of Nephrology, Journal of Immunology.