EvoBiotech is an emerging company focused on developing a technology platform based on plant-derived extracellular vesicles. It was founded in 2019 by a team of experts in the extracellular vesicle field, to lead to the clinical application of plant-derived extracellular vesicles and offer more efficient and easy-to-use treatment options to patients and caregivers.
EvoBiotech was founded by four members of the major Italian research group specialized in the study of extracellular vesicles and their application in the field of regenerative medicine. In fact, the biomedical research team is run by Professor Giovanni Camussi, a leading expert on stem cells and a worldwide pioneer in the research on extracellular vesicles. Their first discovery goes back to 2007, when Professor Camussi and Dr. Deregibus demonstrated that extracellular vesicles act as mediators in the exchange of information between cells.
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During the following years, Professor Camussi’s research team closely studied how extracellular vesicles function and their role in healthy organisms, tumors, and other pathologies. Extracellular vesicles, and specifically extracellular vesicles released by stem cells, are particularly interesting for their regenerative properties. In fact, these vesicles can enter into cells that are damaged by a pathologic condition (such as ischemia or fibrosis), reprogram the behavior of the cell and activate processes for the restoration of the damage. An essential part of the research activity has also been dedicated to studying the techniques of purification and characterization of extracellular vesicles, as well as their composition and therapeutic potential.
Significant efforts are made to advance the clinical use of extracellular vesicles. In this context, the research on the engineering of extracellular vesicles to improve their therapeutic effect represents an essential tool. EvoBiotech’s team can claim a strong expertise in the engineering methods for extracellular vesicles and their therapeutic use.
Since 2016, our research has focused on a new source of extracellular vesicles: edible plants. Plant extracellular vesicles have extraordinary intrinsic biological properties, which make them an ideal tool to evolve current treatments.
Using plants as a source for extracellular vesicles, we can overcome several limitations of other starting materials, such as human cells, especially in terms of yield, costs, and manufacturing time, but also in terms of safety. Plant extracellular vesicles can be easily used to improve therapeutic efficacy and/or drug delivery in clinical applications.